Table 3.
Evidence for secondary signals of association at IL23R, ERAP1 and HLA-B27
WTCCC2 discovery sample |
TASC discovery sample |
Replication sample |
Combined | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Chr. | SNP ID | Positiona | Conditional on SNP |
Effect allele |
P | OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P |
1p31 | rs11209032 | 67,512,680 | rs11209026 | A | 7.9 × 10−6 | 1.20 | 1.11–1.30 | 0.0018 | 1.17 | 1.06–1.29 | 0.0018 | 1.14 | 1.05–1.23 | 5.1 × 10−10 |
5q15 | rs10050860 | 96,147,966 | rs30187 | C | 0.0025 | 1.17 | 1.06–1.30 | 0.026 | 1.16 | 1.02–1.33 | 0.00023 | 1.22 | 1.10–1.35 | 1.9 × 10−7 |
6p21 | rs13202464 | 31,452,562 | rs4349859b | A | 3.7 × 10−7 | 0.32 | 0.21–0.47 | 2.1 × 10−15 | 0.15 | 0.09–0.23 | 2.0 × 10−9 | 0.34 | 0.25–0.47 | 1.1 × 10−29 |
NCBI human genome build 36 coordinates.
We assumed a dominant model for the risk allele at this SNP.