. 2013 Mar 21;56(8):3217–3227. doi: 10.1021/jm301588r

Table 3. pIC₅₀ Values, Ligand Efficiencies, clogP Values, and Lipophilic Ligand Efficiencies for Compounds 3, (+)-8, and 9.

compd	BRD4(1)^a IC₅₀ (μM)	pIC₅₀	ligand efficiency	clogP ^b	lipophilic ligand efficiency
3	4.80	5.32	0.39	2.2	3.12
(S)-(+)-8	0.382	6.42	0.41	2.5	3.92
9	0.371	6.43	0.36	2.6	3.83

Protein and peptide concentration: 50 nM.

clogP was calculated using ACD/Labs (algorithm version 5.0.0.184).

Table 3. pIC50 Values, Ligand Efficiencies, clogP Values, and Lipophilic Ligand Efficiencies for Compounds 3, (+)-8, and 9.