Table 4. Effect of 8, 9, and 15 in Cancer Cell Linesa.
| IC50 (μM) |
||||
|---|---|---|---|---|
| cell line | 8 | 9 | 15 | (+)-JQ1 (1) |
| MV4;11 (AML) | 0.794 | 0.616 | 2.9 | 0.242 |
| A549 (lung adenocarcinoma) | >10 | >10 | ||
| H1975 (lung adenocarcinoma) | >10 | >10 | ||
| U2OS (osteosarcoma) | >100 | >100 | >100 | |
| HeLa (cervical adenocarcinoma) | >100 | >100 | >100 | |
a
For MV4;11, A549, and H1975 cells, viability was assessed after a 72 h incubation using MTS. For U2OS and HeLa cells, viability was assessed after a 24 h incubation using WST-1. Further details are provided in the Supporting Information.