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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Inorg Chem. 2013 Mar 21;52(7):4084–4096. doi: 10.1021/ic400227k

Figure 2.

Figure 2

Structures of DOTA and DO3A and strategies for conjugation of Gd chelates of DOTA-like ligand (A) and DO3A derivatives (B – D). (A) DOTAGA: an example of substitution on the acetate arm with internal motion possible about multiple single bonds. (B) DOTAla: dual anchor strategy with blocked rotation. (C) DOTA-monoamide: direct amide coupling to an acetate arm; restricted rotation but slow water exchange. (D) DO3A derivative: alkylation of a nitrogen atom in the macrocycle; restricted rotation.