Table 3.
Time required to reach 80% of R1 (t = 0) and values of R1 (t = 24 h) for Gd complexes
Compound | Time to 80% R1 [h] |
% R1 (t = 24 h) |
% R1 (t = 24 h) phosphate only |
---|---|---|---|
[Gd(DO2A)] | N/Aa | 0 | 0 |
[Gd(DTPA)] | 2.96 | 45 | inert |
[Gd(DO3A)] | inert | inert | inert |
[Gd(HP-DO3A)] | inert | inert | inert |
[Gd(L1)] | < 0.5 | 0 | 18 |
[Gd(L2)] | 11.4 | 64 | 96 |
[Gd(L3)] | 1.81 | 11 | 58 |
[Gd(L4)] | < 0.5 | 0 | 0 |
[Gd(L5)] | 1.04 | 0 | 25 |
[Gd(L6)] | 1.30 | 9 | 16 |
Values calculated from biexponential fits of the experimental data.
Value could not be reliably determined due to nonstandard behavior.