Table 1.

Model Parameters

Parameter	Description	Value/Expression
Pm	NO permeability in RBC membrane	0.0415, 0.4, 1 and 40 cm/s (Liu et al., 2007; Tsoukias and Popel, 2002; Vaughn et al., 2001)
δ	Thickness of RBC membrane	7×10−3 µm (Malinski et al., 1993)
${\mathrm{D}}_{\text{NO}}^{\text{pl}}$	NO diffusivity in plasma	3.3×10−5 cm2 s−1 (Malinski et al., 1993; Vaughn et al., 1998)
${\mathrm{D}}_{\text{NO}}^{\mathrm{m}}$	NO diffusivity in RBC membrane	Pm × δ
${\mathrm{D}}_{\text{NO}}^{\text{cyt}}$	NO diffusivity in RBC core	1.6×10−5 cm2 s−1(Goldstick et al., 1976; Malinski et al., 1993)
kHb–NO	NO-Hb reaction rate constant	2.5×107 and 8.9×107 M−1s−1(Cassoly and Gibson, 1975; Eich et al., 1996; Herold et al., 2001)
kNO–O2	NO autooxidation rate constant	9.6×106 M−2 s−1
rrbc	Radius of RBC	2.8 µm (Fung, 1997)
CHb	Hemoglobin concentration in RBC	20.3 mM (Altman and Katz, 1971)
CO2	Oxygen concentration	27 µM (Kavdia and Popel, 2003)
${\mathrm{C}}_{\text{NO}}^{\text{out}}$	NO concentration outside unstirred plasma layer	1, 10, 100 and 1000 nM