Table 3.

Striatal Dopamine Response to methylphenidate, as measured by the change in striatal D₂ receptor Binding Potential after methylphenidate administration, in patients with Bulimia Nervosa (BN) and controls (CTR). ^a (A more negative displacement indicates a greater release of DA.)

Region	Δ BPND (BN)	ΔBPND (CTR)	p
Striatum, whole	−10.5% ± 7.7%	−15.1% ± 5.7%	0.07*
Ventral striatum	−11.3% ± 8.5%	−9.7% ± 7.7%	0.60
Putamen, anterior	−8.5% ± 7.5%	−13.9% ± 6.2%	0.04*
Putamen, posterior	−14.8% ± 12.5%	−23.7% ± 10.1%	0.05*
Caudate, dorsal	−5.8% ± 6.8%	−8.4% ± 6.4%	0.31
Caudate, posterior	−8.5% ± 14.5%	−10.7% ± 10.6%	0.65

^aAbbreviations: BP_ND = binding potential; SD = standard deviation; BN = bulimia nervosa; CTR = control participants