Figure 1.

Active sites of (a) CA II, showing ordered waters involved in proton transfer (PDB entry 3ks3; Avvaru et al., 2010 ▶), (b) CA II in complex with AZM (PDB entry 3v2j; this study) and (c) CA II in complex with AZM and GOL (PDB entry 3hs4; Sippel et al., 2009 ▶). Hydrogen bonds are shown as black dotted lines. Waters are colored in gradients of blue from dark (not displaced) to light (AZM displaced) to lighter (GOL displaced). The active-site Zn²⁺ ion is shown as a magenta sphere. This figure was produced using PyMOL (http://www.pymol.org).