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. 2013 Mar 20;33(12):5152–5161. doi: 10.1523/JNEUROSCI.3390-12.2013

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Copyright © 2013 the authors 0270-6474/13/335152-10$15.00/0

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Figure 7. — Effect of depletion of descending 5-HT on the maintenance of neural hyperexcitability in the Vc at 14 d after CCI-ION. Pooled data are collected from Vc neurons in CCI-treated rats with Tph-2 shRNA (22 neurons) and control shRNA (n = 12). A, RF sizes of Vc WDR neurons in CCI-ION rats post-treated with control shRNA were significantly larger than RF sizes in naive rats (p < 0.001 vs naive). However, there was no difference in the RFs sizes between Tph-2 shRNA-treated and control shRNA-treated groups after CCI-ION. B, The percentage of neurons exhibiting spontaneous activity in Vc neurons at 14 d post-CCI-ION was similar in rats receiving Tph-2 shRNA (41%) compared with rats receiving control shRNA (31%). No Vc neurons in naive rats had spontaneous activity. C, D, Depletion of descending 5-HT attenuated the postdischarge frequency (C) and duration (D) of neuronal poststimulus discharges. ***p < 0.001, vs control shRNA.