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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2008 Dec 9;235(1):47–56. doi: 10.1016/j.taap.2008.11.018

Figure 5. Chromium Induces Injury and Inflammation in the Lung.

Figure 5

Bright field microscopy pictures taken of lung sections obtained from mice up to 48 hrs post-Cr(VI) exposure to 50 µL of 1.2 mg/mL basic zinc chromate suspended in saline. Sections were stained with H&E and images were taken at 10× (A, C) and 40× (B, D) original magnification. B) Chromate-exposed animals exhibit proximal and mid-proximal toxic airway mucosal injury with sloughing of airway epithelial cells (*), degenerative changes, and periductal inflammation (red arrows). C) Injury in chromate-exposed animals is primarily located in the central region of the lungs while near-pleural lung regions show less response to chromate treatment at 24 hrs. D) Chromate-exposed animals exhibit parenchymal inflammation with features of alveolar and interstitial pneumonitis and in the central regions of the lungs at 48 hrs post-chromate exposure.