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. 2013 Feb 19;5(2):363–375. doi: 10.3390/toxins5020363

Figure 1.

Figure 1

Comparison among NK22 cells and NK17/NK1 cells. While NK22 cells are found in tissues, such as tonsils and peyers patches, NK17/NK1 cells are generated from human blood after activation in vitro with IL-2 and are abundant in the CSF of MS patients without activation. NK22 cells express the NK cytotoxicity receptor NKp44, whereas NK17/NK1 cells express NKp30, NKG2D, as well as NKp44, NKp46 and CD158, but to a lower extent than the other NK cell cytotoxicity receptors. Whereas NK22 cells express CCR6, secrete and respond CCL20/MIP-3α, NK17/NK1 cells express CCR4, secrete and respond to CCL22/MDC. As for the transcription factors, NK22 cells express RORγ, AHR, RORα and IRF4, while NK17/NK1 cells express RORγ and T-bet and, consequently, secrete both IL-17 and IFN-γ.