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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Arch Pathol Lab Med. 2012 May;136(5):517–526. doi: 10.5858/arpa.2011-0147-OA

Fig 3. Carcinoma in situ (CIS) and invasive urothelial carcinoma.

Fig 3

Multiphoton microscopy (MPM) image (A) and the corresponding H&E image (B) at low magnification showing flat urothelium with loss of polarity (a) and underlying lamina propria (b). MPM image (C) and corresponding H&E image (D) at high magnification showing high grade cytologic features [marked pleomorphism and increased Nuclear:Cytoplasmic (N:C) ratio; arrow]. MPM image (E) and corresponding H&E image (F) at high magnification showing nests of invasive tumor cell (a; color-coded green) in collagen fibers of lamina propria (b; color-coded red). (MPM magnifications: A=48X, C=293X, E=480X; H&E magnifications: B=40X, D=200X, F=400X)