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. Author manuscript; available in PMC: 2014 Mar 13.
Published in final edited form as: J Am Chem Soc. 2013 Mar 1;135(10):4117–4128. doi: 10.1021/ja400315y

Table 1.

Activity against invasive prostate cancer (DU145) and melanoma (A2508) cell lines.a

Entry Structure DU145
IC50 		A2058
IC50
1 graphic file with name nihms451827t1.jpg R = Me (6)
gliocladine C		 0.43 μM 0.68 μM
2 R = i-Pr (7)
leptosin D		 0.29 μM 0.85 μM
3 R = CH2OH (8)
T988C		 0.53 μM 0.96 μM
4 R = H (9) 0.70 μM 2.0 μM
5 graphic file with name nihms451827t2.jpg R = Me (32) 0.26 μM 0.96 μM
6 R = i-Pr (43) 0.39 μM 1.0 μM
7 R = CH2OH (54) 0.50 μM 1.2 μM
8 graphic file with name nihms451827t3.jpg R = H (46) 2.8 μM 4.0 μM
9 R = Ac (45) 2.5 μM 4.2 μM
10 graphic file with name nihms451827t4.jpg 0.85 μM 1.8 μM
11 graphic file with name nihms451827t5.jpg 2.3 μM 3.8 μM
12 graphic file with name nihms451827t6.jpg >5 μM >5 μM
13 ent-gliocladine C 0.68 μM 0.35 μM
14 graphic file with name nihms451827t7.jpg 0.073 μM 0.061 μM