Table 1.
Substrates | Enzymes | Imaging technology | Purpose |
---|---|---|---|
[18F] FEAU | TK | PET | Imaging |
[18F]FHBG | TK | PET | Imaging |
[124I] FIAU/[131I]FIAU | TK | PET/SPECT | Imaging/therapy |
5-FC | bCD/yCD | 19F MRS/MRSI | Therapy |
5-FU | UPRT | 19F MRS/MRSI | Therapy |
3,5-DFBGlu | CPG2 | 19F/13C MRSI | Imaging |
L-[18F] FAC/L-[18F]FMAC | dCK | PET | Imaging |
5-FC 5-fluorocytosine, 5-FU 5-fluorouracil, TK thymidine kinase, bCD bacterial cytosine deaminase, yCD yeast cytosine deaminase, UPRT uracil phosphoribosyltransferase, CPG2 carboxypeptidase G2, dCK deoxycytidine kinase, PET positron emission tomography, SPECT single-photon emission computed tomography, MRS magnetic resonance spectroscopy, MRSI magnetic resonance spectroscopic imaging