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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: J Neurochem. 2013 Apr 1;125(4):555–565. doi: 10.1111/jnc.12234

Fig. 1. Effect of methamphetamine pretreatment on body temperature and dopamine innervation in the dorsal striatum.

Fig. 1

(A) METH treatment resulted in significantly increased body temperatures relative saline-treated controls. Arrows indicate time of METH injections. Data are average rectal temperatures (°C; mean±SEM, n=15 for saline-treated and n=15 for METH-treated). *Significantly different from saline-treated rats at the same time point. BL, baseline; **p<0.001, ***p<0.0001. (B) Representative images of [125I]RTI-55 striatal DAT binding in a saline- and METH-pretreated rat 3–5 weeks after METH pretreatment. (C) METH pretreatment resulted in partial dopamine denervation in both the dorsomedial (DMS) and dorsolateral (DLS) striatum 3–5 weeks after METH pretreatment as assessed by [125I]RTI-55 binding to dopamine transporters. Data are presented as percent of saline-pretreated values (±SEM, n=15 for saline-pretreated and n=15 for METH-pretreated). *Significant effect of METH pretreatment. **p<0.001, ***p<0.0001.