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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: NMR Biomed. 2011 Apr 27;24(6):592–611. doi: 10.1002/nbm.1661

Table 2. Effectors and Inhibitors of Inducible Mobile Lipid in Cell Models.

Mobile Lipid Effector Cell/Tissue Type Mobile Lipid Inhibitor Reference
Culture Conditions

Low pH Transformed murine L fibroblasts C6 glioma cells Reversible at neutral pH [16][44, 68]
High cell density Transformed murine L fibroblasts C6 glioma cells [16][41, 42, 44, 68]
Cell subculture HeLa cells Time in culture [152]
MCF-7 cells [153]
Grown in culture Human peripheral blood monocytes [24]
Serum deprivation Transformed murine L fibroblasts [16]
Jurkat T lymphoblasts [72]
Serum Mixed peripheral blood cells [24]
Human neutrophils [21, 78]
Unsaturated fatty acids Neutrophils [21]
AgX63.653 murine spleen myeloma cells [154]
Autologous monocyte co-culture Human peripheral blood lymphocytes [24, 81]
Growth as spheroids GaMG human glioma cell line [155]
Senescence, extended passaging Human fibroblasts [82]

Anticancer drugs and inhibitors

Antimetabolites
 5-fluorouracil Transformed HBL-100 breast cells Chlorpromazine [70, 87]
Microtubule stabilizers
 Paclitaxel Human erythroleukemia K562 cells [73]
 Liposome encapsulated BT-20, MCF-7 breast cancer cells [76]
Microtubule depolymerizers
 Colcemid Jurkat T lymphoblasts [72]
Topisomerase II inhibitors
 Etoposide HeLa cervical carcinoma cells [74]
Murine EL-4 lymphoma cells [95]
Antitumor antibiotics
 Daunorubicin Jurkat T lymphoblasts [40, 72]
 Doxorubicin Jurkat T lymphoblasts [40, 71, 72]
Daudi B-lymphoma [72]
JY lymphoblastic leukemia [72]
HL60 leukemia cells Bcl-2 transfection [71, 72, 75]
Glucocorticoids Jurkat T lymphoblasts [40, 72]
 Dexamethasone
Fas monoclonal antibodies Jurkat T lymphoblasts [48]
Hut 78, human lymphoblast cell line Triacsin C [85]
Differentiating agents
 Phenylacetate DU145 prostate cells [46]
 Phenylbutyrate PPAR-γ antagonists [45, 46, 77]
AACOCF3 [88]
Cationic lipophilic phosphonium salts DU4475 breast cancer cells [20, 70]
Transformed HBL-100 breast cells Chlorpromazine [2, 47, 69, 70]
Cyclosporin A Transformed HBL-100 breast cells Chlorpromazine [86]
 Cell cycle blockers [1]
 Desferrioxamine, ADR 529 2609 Glioma cells [152]
 Lonidamine HeLa cells
PC-PLC inhibitors
 D-609 NIH-3T3 mouse embryo fibroblasts Ras-transformation [83, 84]
Thiazolidinediones
 Troglitazone 3T3 F442A cells [156]

Mitogens and Cytokines

Phorbol myristate acetate ± ionomycin Jurkat T lymphoblasts [40, 157]
Murine splenic and thymic T cells [22, 23, 79, 80]
Human peripheral blood lymphocytes [81]
Concanavalin A Murine splenic T cells [22, 26, 78]
Anti-CD3 antibodies Murine splenic and thymic T cells D-609 [80]
Human peripheral blood lymphocytes [80, 81]
Lipopolysaccharide Murine splenic B cells, Human neutrophils [21, 26, 158, 159]
Interferon-γ Mouse peritoneal macrophages [24, 25]

Other

Listeria monocytogenes Mouse peritoneal macrophages [24, 25]
Ionizing radiation HL60 leukemia cells [75]
MG-63 human osteosarcoma spheroids [160, 161]
HIV-1 infection Lymphoblastoid cells Transient [162]
Bacterial infection Human neutrophils [159]
Caveolin-1 transfection K562 myelogenous leukemia cells [163]
K562 myelogenous leukemia cells Taxol adriamycin resistance [164]
MCF-7 breast cells, LoVo colon adenocarcinoma cells Multidrug resistance [165]