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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Trends Cell Biol. 2013 Feb 1;23(5):242–250. doi: 10.1016/j.tcb.2013.01.004

Figure 3.

Figure 3

Pathway for Cytoplasmic 60S maturation. Adapted from [83]. Release of the Arx1/Alb1 complex from the exit tunnel requires the Hsp70 ATPase Ssa and its co-chaperone Jjj1, and has the ability to check the binding site for Ssa on the exit tunnel. Exchange of Mtr4 with P0 and subsequent stalk assembly requires Yvh1. Both events can occur independently of each other but are both required for the Efl1/Sdo1-dependent release of eIF6/Tif6. Efl1 function tests the P-site [86] as well as the stalk [83]. The final step in 60S maturation is the Lsg1-dependent release of Nmd3.