. Author manuscript; available in PMC: 2013 May 1.

Published in final edited form as: Genes Immun. 2011 Jun 9;12(8):615–625. doi: 10.1038/gene.2011.34

Table 4.

Associations in this study with genes identified in previous GWAS of MSSS^a

Locus	Chr	Median MSSS (≤5 vs >5)			Extreme MSSS (<2.5 vs ≥7)			Continuous MSSS
		SNP	OR	P-value	SNP	OR	P-value	SNP	β	P-value
AKAP12	6	rs17080959	1.42	0.0024	rs17080959	1.77	0.00065	rs17080959	0.45	0.00072
CAMK2D	4	rs987694	1.30	0.0016	rs17531554	1.51	0.0075	rs11729444	0.45	0.00036
CDH4	20	rs6089621	1.90	0.0015	rs13040920	0.61	0.00014	rs2066422	−0.40	0.00035
CSMD1	8	rs9644362	1.48	0.0014	rs9772485	1.71	0.00026	rs4875322	−0.36	0.00086
GRIN2A	16	rs1448239	1.65	3.0×10−5	rs1448239	1.89	0.00020	rs1448239	0.56	3.2×10⁻⁵
GSG1L	16	rs205420	0.71	0.00045	rs205370	0.70	0.0035	rs205418	−0.32	0.0027
KDM4C	9	rs2792226	0.79	0.0085	rs10975870	0.18	0.00016	rs10975869	−1.79	0.00010
MACROD2	20	rs10485772	1.74	0.0010	rs4814386	1.68	0.00011	rs6079855	0.42	0.00017
MAGI2	7	rs246462	0.79	0.0082	rs6958768	1.53	0.0055	rs9886142	0.51	0.00084
MTHFD1L	6	rs7349940	1.64	0.00081	rs6557106	0.72	0.0066	rs7349940	0.50	0.0031

Abbreviations: Chr, chromosome; GWAS, genome-wide association study; MSSS, multiple sclerosis severity score; OR, odds ratio; SNP, single-nucleotide polymorphism.

Genes listed have at least one SNP significantly associated at P<0.001 in at least one of the MSSS meta-analyses. Genes were excluded if there was only one significant SNP association (P<0.05) in any meta-analysis. This shows overlapping associations (with gene) reported in a previous independent GWAS of MSSS (P<0.0001).²¹