Table 4.
TAA | EAA | |||||
---|---|---|---|---|---|---|
Protein synthesis | 185.4 | ± | 8.7 | 197.1 | ± | 11.6** |
Protein breakdown | 159.6 | ± | 7.0 | 171.1 | ± | 10.7 |
Net Protein synthesis | 25.8 | ± | 3.0 | 38.2 | ± | 4.6*** |
Splanchnic extraction | 0.50 | ± | 0.04 | 0.47 | ± | 0.05p=0.06 |
WbRa Leucine | 372.8 | ± | 17.7 | 645.5 | ± | 41.6*** |
WbRa Arginine | 439.7 | ± | 33.3 | 394.5 | ± | 31.4*** |
WbRa Citrulline | 47.8 | ± | 3.8 | 44.8 | ± | 3.0 |
Q Citrulline to Arginine | 52.2 | ± | 5.0 | 47.1 | ± | 4.1p=0.09 |
Q Arginine to Citrulline | 1.3 | ± | 0.3 | 0.9 | ± | 0.2 |
Values are means ± SEM and expressed in nmol/kg ffm/3h. CF: Cystic Fibrosis, WbRa: Whole body rate of appearance, Q Citrulline to Arginine: de novo arginine synthesis rate, Q Arginine to Citrulline: Nitric oxide production rate. Significance of difference after intake of the total amino acid mixture (TAA) and the essential amino acid mixture (EAA):
: P < 0.01,
: P<0.001.