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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Int J Dev Neurosci. 2013 Mar 7;31(4):258–266. doi: 10.1016/j.ijdevneu.2013.02.009

Figure 1. Chronic Morphine Administration in Newborn Rats.

Figure 1

Graph illustrates the effect of repeated morphine exposure on the body mass of newborn rats. Day of birth was considered day 0 of life. Morphine sulfate (10 mg/kg sc twice-daily) or equivalent volume of normal saline was injected for 6 ½ days starting on the postnatal day (PD) 1. Systemic morphine exposure (n=17) significantly decreased body mass (± SD) in newborn rats in comparison to normal saline control group (n=30). There were no differences between naïve (n=6) and normal saline groups (not shown). Two-tailed t-Test: *, p<0.05; **, p<0.01.