Table 1.

Allelic association of rare non-synonymous SNPs in OPRM1 with heroin or cocaine addiction. Addicted alleles show the minor allele count in the heroin/cocaine addicted population and the NHLBI-ESP alleles show the allele count according to the NHBLI-ESP database.

SNP	Location	Addicted Alleles	MAF	NHLBI-ESP Alleles	MAF	P-Value	OR (95% C.I.)
European Americans
rs17174794	S147C	26/2628	0.99%	56/8456	0.66%	0.19	1.49 (0.94–2.38)
rs62638690	C192F	10/2644	0.38%	67/8389	0.79%	0.02	0.47 (0.24–0.92)
African Americans
rs17174801	N152D	17/1865	0.9%	34/4234	0.80%	0.65	1.14 (0.63–2.04)
rs1799971	N40D	52/1934	2.62%	122/3862	3.06%	0.57	0.92(0.66–1.26)

MAF= minor allele frequencies, OR = odds ratio, 95% C.I. = confidence intervals.