Table 2.
Mean (±SE) level of plasma lipids, lipoproteins and phospholipid fatty acids across APOE genotypes1
| APOE allele23 | |||
|---|---|---|---|
| E2 (n=333) | E3 (n=1459) | E4(n=548) | |
| Lipid profile | |||
| Triglyceride, Geometric mean, mmol/L | 1.36±0.01 | 1.28±0.01 | 1.34±0.01 |
| Total Cholesterol, mmol/L | 4.82±0.05b, c | 5.12±0.02a | 5.15±0.04a |
| LDL-C, mmol/L | 2.74± 0.04b, c | 3.13± 0.02a | 3.20± 0.03a |
| HDL-C, mmol/L | 1.36±0.02b, c | 1.31±0.01a, c | 1.26±0.01a, b |
| Lipoprotein characteristics | |||
| Small LDL conc. (18-20.5 nm), nmol/L | 450.3± 20.0b, c | 548.4± 9.4a, c | 621.8± 15.6a, b |
| Large LDL conc. (20.5-23 nm), nmol/L | 491.2± 13.1b, c | 608.8± 6.2a | 592.9± 10.3a |
| Mean LDL particle size, nm | 20.73±0.03 | 20.76±0.01c | 20.66±0.02b |
| Total LDL conc., nmol/L | 1081.3± 18.5b, c | 1287.6± 8.77a, c | 1336.3± 14.4a, b |
| Small HDL conc. (7.3-8.2 nm), μmol/L | 14.5±0.3 | 14.6±0.1 | 14.9±0.2 |
| Medium HDL conc. (8.2-9.4 nm), μmol/L | 14.4± 0.3b, c | 13.0± 0.2a, c | 12.2± 0.3a, b |
| Large HDL conc. (9.4-14 nm), μmol/L | 6.1±0.2 | 6.0±0.1 | 5.7±0.1 |
| Mean HDL particle size, nm | 9.24±0.02 | 9.26±0.01 | 9.25±0.02 |
| Total HDL conc., μmol/L | 34.9±0.3b, c | 33.6±0.2a, c | 32.7±0.3a, c |
| Plasma phospholipid omega-3 fatty acids | |||
| EPA, % | 0.93±0.05 | 0.96±.02 | 0.96±0.04 |
| DHA, % | 4.08±0.07 | 4.17±0.03 | 4.11±0.06 |
1
Adjusted for age, sex, race, field center, ancestry informative marker principal components (PC1-PC5), education, smoking status, alcohol use, total intentional exercise, BMI, diabetes.
2
E2=genotypes E2/E2 and E2/E3, E3=genotype E3/E3, and E4=genotypes E3/E4 and E4/E4.
3
Difference observed between groups (ppdiff < 0.017)
a
different from E2
b
different from E3
c
different from E4.