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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Nature. 2012 Sep 9;489(7417):576–580. doi: 10.1038/nature11355

Figure 3. Fun30 plays a direct role in DSB ends resection.

Figure 3

a. ChIP analysis of Fun30-13xMyc recruitment at DSB. b. Recruitment of resection enzymes analyzed by ChIP. Statistically significant differences in protein enrichment are indicated by “*” (P<0.05) or “**” (P<0.01, t-test). Relative enrichment in fun30Δ is shown. c. Analysis of resection kinetics in indicated FUN30 mutants. The level of mutant proteins and their recruitment to DSB were comparable to wild-type Fun30 (Fig. S5). d. ChIP analysis of Fun30-13xMyc recruitment in mutants deficient in resection or DNA damage checkpoint. Recruitment at the ARO1 locus was used as a control.