TABLE 2.

Effects of Addictive Drugs on Adult Hippocampal Neurogenesis in Rodents

Drug	Neurogenic Effects by Dosing			Cell Death Effects*	Author, Year
	Acute	Chronic	Withdrawal
Nicotine		↓P		↑	Abrous, 2002
Nicotine		↓D/S			Shingo, 2005
Nicotine		↓P			Scerri, 2006
Nicotine	0P				Mudo, 2007
Alcohol	↓P	↓P/S			Nixon, 2002
Alcohol		↓S		↑	Herrera, 2003
Alcohol		↓P	↑P		Nixon, 2004
Alcohol		↓P/S		↑	He, 2005
Alcohol	↓P/S				Crews, 2006
Alcohol			↑P		Nixon, 2008
Alcohol		↓S			Hernandez-Rabaza, 2010
Alcohol		↓P			Alen, 2010
Opioids	0P	↓P/S			Eisch, 2000
Opioids		↓P			Mandyam, 2004
Opioids		↓P/D	↑P		Kahn, 2005
Opioids	0P	↓P			Fisher, 2008
Opioids		↓P/D		↑	Arguello, 2008
Opioids		↓P			Arguello, 2009
Cocaine	0P	↓P			Yamaguchi, 2004
Cocaine	0P	↓P			Yamaguchi, 2005
Cocaine	↓P	↓P		0	Dominguez-Escriba, 2006
Cocaine		↓P	↑P/D	0	Noonan, 2008
Cocaine	0P	↓P/S	↓P/S		Garcia-Fuster, 2010
Amphetamine (meth)	↓P		0		Teuchert-Noodt, 2000
Amphetamine	0P				Mao, 2001
Amphetamine (meth)	↑P/D	↓P/D/S		↑	Mandyam, 2008
Amphetamine		0P/S	↓S	0	Barr, 2010
Amphetamine(meth)		↓P	↑P/S	↑	Recinto, 2011
Methylphenidate		0P	↓S		Lagace, 2006
MDMA		↓P			Cho, 2007
MDMA		↓S			Hernandez-Rabaza, 2010
Cannabinoids		↑P/D	synthetic		Jiang, 2005
Cannabinoids		0P	D9-THC		Kochman, 2006
Cannabinoids		0P/D	synthetic		Mackowiak, 2007
Cannabinoids		↓P	synthetic		Alen, 2010

0 =no change found

↑ increase

↓ decrease

P=Proliferation

D=Differentiation (e.g. into neurons)

S=survival

^*Drug shown to kill neurons as evidenced by markers that may label either old or young DG neurons All data restricted to rodent models