. Author manuscript; available in PMC: 2013 May 1.

Published in final edited form as: Kidney Int. 2010 Dec 15;79(6):663–670. doi: 10.1038/ki.2010.484

Table 2.

Demographic, renal functional and glomerular structural parameters of Fabry patients and controls.

	Fabry Males (n=8)	Fabry Females (n=6)	Fabry Total (n=14)	Controls (M/F=6/3) (n=9)	p-value
Age (years)	14[4–19]	12[8–14	12[4–19]	32[16–52]	0.0005^‡, 0.0008^, 0.0009^*
UPCR (mg/g)	55±90	18±25	40±71	NA	NS^†
Serum Cr (mg/dl)	0.70±0.15 (n=6)	0.63±0.12 (n=5)	0.65±0.13 (n=11)	NA	NS^†
GFR (ml/min/1.73m²)	120±37 (n=5)	101±8 (n=5)	111±27 (n=10)	NA	NS^†
Vv(Inc/PC)	0.37±0.11	0.26±0.06	0.32±0.11	--	0.06^†
Vv(Inc/Endo)	0.19±0.12	0.03±0.03	0.12±0.12	--	0.008^†
Vv(Inc/Mes)	0.08±0.06	0.03±0.03	0.06±0.05	--	0.06^†
FPW (nm)	558±133	455±67	514±118	430±61	0.06^‡, 0.06^†, 0.01^**
% endothelial fenestration	48±14	49±9	48±12	61±9	0.01^‡, 0.06^, 0.03^*

All values are mean±SD except for age and urine protein creatinine ratio which are median [range]. To convert UPCR from mg/g to mg/mmol; multiply by 0.887. which are median [range].

Female Fabry vs. control;

^**

male Fabry vs. control;

^†

male vs. female Fabry;

^‡

combined male and female Fabry vs. control.

Abbreviations: UPCR= urinary protein creatinine ratio; S/Cr= serum creatinine; GFR=glomerular filtration rate; Vv(Inc/PC)=fractional volume of podocyte GL-3 inclusions per cytoplasm; Vv(Inc/Endo)= fractional volume of endothelial cell GL-3 inclusions per cytoplasm; Vv(Inc/Mes)=mesangial cell GL-3 inclusions per cytoplasm; FPW=foot process width