Table 2.
Observational estimates for uric acid adjusted for age and gender with individual phenotypes compared with corresponding genotype-based mean phenotype values and additive model point estimates for each Ile allele and corresponding P-value
| Trait (n=868) | Serum UA correlations
|
GLUT9 genotype-based approach
|
|||||
|---|---|---|---|---|---|---|---|
| Estimate (s.e.) | P-value | Ile/Ile mean (s.d.) | Val/Ile mean (s.d.) | Val/Val mean (s.d.) | Effect estimate | Additive P-value | |
| Uric acid, mg/dl | — | — | 3.39 (1.46) | 3.90 (0.98) | 4.29 (1.00) | 0.44 (0.06) | 3.2 ×10−11 |
| Estimated GFR (ml/min) | −4.5 (0.58) | 1.38 ×10−14 | 89.0 (15.8) | 95.7 (18.2) | 96.0 (18.7) | 0.42 (1.12) | 0.706 |
| Body mass index (kg/m2) | 1.71 (0.14) | 1.52 ×10−31 | 28.4 (5.0) | 26.3 (4.3) | 26.7 (4.6) | 0.24 (0.29) | 0.393 |
| Triglycerides | 14.2 (1.35) | 2.25 ×10−24 | 71.8 (40.6) | 67.3 (42.9) | 69.4 (42.9) | 2.38 (2.68) | 0.347 |
| Glucose | 2.47 (0.44) | 2.48 ×10−8 | 87.2 (5.7) | 85.4 (7.5) | 86.6 (10.3) | 0.78 (0.84) | 0.36 |
| Clinic visit 1 SBP | 1.91 (0.48) | 7.63 ×10−5 | 115.5 (14.5) | 122.2 (14.0) | 121.4 (15.0) | 0.08 (0.91) | 0.378 |
| Clinic visit 1 DBP | 1.36 (0.3) | 7.71 ×10−6 | 75.7 (7.2) | 76.4 (8.9) | 76.9 (8.7) | 0.52 (0.58) | 0.364 |
| High-salt 24-hr SBPa | 2.28 (0.51) | 8.73 ×10−6 | 112.2 (8.2) | 115.3 (9.0) | 117.6 (10.8) | 2.2 (0.79) | 0.006 |
| High-salt 24-h DBPa | 1.53 (0.38) | 6.41 ×10−5 | 69.4 (5.8) | 70.0 (6.2) | 70.6 (6.6) | 0.42 (0.5) | 0.406 |
| Low-salt 24-h SBPa | 1.87 (0.49) | 1.38 ×10−4 | 110.5 (7.0) | 115.1 (8.7) | 116.5 (9.0) | 1.48 (0.71) | 0.038 |
| Low-salt 24-h DBPa | 0.88 (0.35) | 0.012 | 69.7 (6.0) | 71.3 (6.3) | 71.8 (6.0) | 0.19 (0.48) | 0.689 |
| Salt sensitivity 24-h SBP | −0.01 (0.17) | 0.954 | 1.71 (4.3) | 0.48 (4.6) | 1.05 (5.6) | 0.62 (0.49 | 0.212 |
| Salt sensitivity 24-h DBP | 0.04 (0.24) | 0.843 | −0.29 (2.3) | −1.22 (3.5) | −1.16 (3.8) | −0.01 (0.31) | 0.986 |
Abbreviations: CI, confidence interval; DBP, diastolic blood pressure; GFR, glomerular filtration rate; SBP, systolic blood pressure; UA, uric acid.
Estimates of serum UA correlations are based on 1 mg/dl change in UA. No significant difference was noted between high- and low-salt diet SBP measures. All blood pressure measurements are given in mm Hg.
a
The 24-h blood pressure measurements were available in a subset of 516 of 868 participants.
Bold indicates P-value<0.05.