. Author manuscript; available in PMC: 2014 Mar 1.

Published in final edited form as: ChemMedChem. 2013 Jan 29;8(3):385–395. doi: 10.1002/cmdc.201200585

Table 12.

NMDA antagonist activity of tetramic acid derivative 73.^[69]

Structure	IC₅₀^[a] [μm]	K_d^[b] [μm]
	0.7	6.15

^[a]

Inhibition of the binding of [³H]-l-689,560 to the strychnine insensitive glycine site on rat brain membranes.

^[b]

Inhibition of NMDA-induced depolarizations in rat cortical slices.