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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: ChemMedChem. 2013 Jan 29;8(3):385–395. doi: 10.1002/cmdc.201200585

Table 13.

Thromboxane A2 (TP) receptor antagonist activity of cyclopentane-1,3-dione derivatives.[74]

graphic file with name nihms-455683-t0046.jpg
Compd X IC50[a] [nm]
mouse human
75 CH2COOH 27 61
76 graphic file with name nihms-455683-t0047.jpg 52 250
77 graphic file with name nihms-455683-t0048.jpg >10000 >10000
78 graphic file with name nihms-455683-t0049.jpg 3.1 131
79 graphic file with name nihms-455683-t0050.jpg 5.8 41
[a]

Results of an IP1 assay using mouse or human TP receptor.