Skip to main content
. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: ChemMedChem. 2013 Jan 29;8(3):385–395. doi: 10.1002/cmdc.201200585

Table 3.

Comparison of sulfonic and carboxylic acid CCK-B receptor antagonists.[22]

graphic file with name nihms-455683-t0019.jpg
Compd X IC50 [nm] pKa
CCKB CCKA
13 CH2COOH 1.7 4500 5.6
15 CH2SO3Na 1.3 1010 <1
14 graphic file with name nihms-455683-t0020.jpg 2.6 1700 6.5
16 CH2P(O)(OH)2 23 2700 3.4, 7.8
17 CH2P(O)(OH)Me 23 4400 3.7