Table 1.

Clinicopathologic findings for patients with EGFR-mutant adenosquamous carcinomas. The majority were diagnosed with squamous cell carcinoma in at least 1 sample.

Patient#	Age	Gender	Race	Smoking	Stage‡	Biopsy #1^	Biopsy #1 Mutation	Biopsy #2^	Biopsy #2 Mutation	Lines of therapy	EGFR TKI line	Best response to EGFR TKI	TTP on TKI(months)	OS (months)
1 (1)	61	M	White	Never	IV	Squamous (L1)†	exon 19 del	Adenosquamous (LLL lung)	exon 19 del	3	2nd line	PR	12.1	27.5
2 (2)	71	F	White	Never	IV	Squamous (RLL lung)†	exon 19 del	Adenocarcinoma (RLL lung)	exon 19 del	2	1st line	Unavailable	19.6	32.9+
3 (3)	58	F	White	Never	IV	Squamous (RUL lung)	exon 19 del	Adenosquamous (LLL lung)†	exon 19 del	3	2nd line	SD	23.6	32.2+
4 (4)	45	F	Hispanic	Never	IV	Squamous (sacrum)	exon 19 del	Adenocarcinoma (pleural fluid)	exon 19 del	2	2nd line	Unavailable	Unavailable	15.3
5 (5)	46	M	Asian	Never	IV	Squamous (R lung)	exon 19 del	Adenocarcinoma (SC LN)	exon 19 del	1	1st line	PR	5.0+	6.6+
6 (6)	73	M	White	Former (25 PY)	IV	Squamous (adrenal)	exon 19 del	Adenocarcinoma (SC LN)	insufficient	2	3rd line	Unavailable	Unavailable	29.8
7 (10)	58	M	Asian	Never	IV	Squamous (bronchus)	L858R	Squamous (T8)	insufficient	1	1st line	PR	1.9	2.5
8 (new)	76	M	White	Never	IV*	Squamous (R lung)†	insufficient	Adenocarcinoma (L lung)	exon 19 del	1	1st line	PR	5.3	5.3+
9 (new)	68	M	White	Never	IV	Squamous (L lung)	L858R	None	N/A	4	4th line	PR	2.8+	24.0+
10 (new)	30	F	Asian	Never	IV	Adenosquamous (R lung)	L858R	None	N/A	2	1st line	PR	8.4	10.9+
11 (new)	50	M	White	Never	IV	Adenosquamous (L lung)	exon 19 del	None	N/A	1	1st line	PR	9.2+	9.6+

^#In parentheses are corresponding patient IDs in reference (8).

^{^}Biopsy numbers are not chronologic: biopsy #1 represents the index case (EGFR mutant “SQCLC”)

^‡Stage at the time of TKI treatment.

^*Prior Stage IIA treated with induction cisplatin + pemetrexed followed by LLL lobectomy

^†Acquired resistance biopsy

Abbreviations: SC LN supraclavicular lymph node, PR partial response, SD stable disease, PY pack years