Table 2.
SNPs with the same trend in both the MD Anderson and Mayo Clinic populations
| Position | Gene | SNP | Model | MD Anderson (discovery)
|
Mayo Clinic (validation)
|
Combined analysisb
|
||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI)a | P | HR (95% CI)a | P | HR (95% CI)b | P | P-het | ||||
| Chr22:15969246 | IL17RA | rs879576 | DOM | 0.57 (0.41–0.78) | 5.49 × 10−4 | 0.65 (0.44–0.94) | 0.023 | 0.60 (0.47–0.77) | 4.13 × 10−5 | 0.610 |
| Chr9:92674234 | SYK | rs290229 | DOM | 1.58 (1.23–2.03) | 3.03 × 10−4 | 1.43 (1.01–2.02) | 0.046 | 1.53 (1.25–1.87) | 4.15 × 10−5 | 0.635 |
| Chr1:39738348 | BMP8A | rs698141 | DOM | 1.89 (1.33–2.68) | 4.04 × 10−4 | 1.73 (1.03–2.91) | 0.038 | 1.84 (1.37–2.46) | 4.29 × 10−5 | 0.789 |
| Chr9:21397604 | IFNA8 | rs4978115 | REC | 1.79 (1.35–2.36) | 4.39 × 10−5 | 1.24 (0.86–1.79) | 0.240 | 1.56 (1.25–1.95) | 7.43 × 10−5 | 0.123 |
| Chr5:149761820 | CD74 | rs1056400 | DOM | 0.58 (0.43–0.78) | 3.54 × 10−4 | 0.71 (0.48–1.04) | 0.080 | 0.62 (0.49–0.79) | 1.00 × 10−4 | 0.403 |
| Chr9:21403703 | IFNA8 | rs13296822 | REC | 1.83 (1.36–2.47) | 7.76 × 10−5 | 1.23 (0.75–2.04) | 0.412 | 1.65 (1.28–2.13) | 1.36 × 10−4 | 0.188 |
| Chr4:15449937 | CD38 | rs10805347 | REC | 0.45 (0.28–0.72) | 7.93 × 10−4 | 0.55 (0.28–1.07) | 0.080 | 0.48 (0.33–0.70) | 1.75 × 10−4 | 0.616 |
| Chr20:36392996 | BPI | rs5743539 | DOM | 2.77 (1.61–4.77) | 2.45 × 10−4 | 1.59 (0.87–2.92) | 0.134 | 2.16 (1.44–3.25) | 1.90 × 10−4 | 0.184 |
| Chr13:101691503 | FGF14 | rs1336726 | ADD | 0.71 (0.58–0.86) | 5.34 × 10−4 | 0.80 (0.60–1.07) | 0.133 | 0.74 (0.63–0.87) | 2.10 × 10−4 | 0.474 |
| Chr16:86446704 | SLC7A5 | rs4240803 | DOM | 0.66 (0.52–0.84) | 8.39 × 10−4 | 0.82 (0.60–1.12) | 0.219 | 0.72 (0.59–0.87) | 6.78 × 10−4 | 0.290 |
| Chr9:92684769 | SYK | rs1755938 | DOM | 1.63 (1.25–2.14) | 3.68 × 10−4 | 1.17 (0.80–1.73) | 0.417 | 1.47 (1.17–1.83) | 7.17 × 10−4 | 0.168 |
| Chr7:2744970 | GNA12 | rs11971014 | DOM | 0.59 (0.44–0.80) | 4.77 × 10−4 | 0.87 (0.58–1.30) | 0.488 | 0.67 (0.53–0.86) | 1.18 × 10−3 | 0.141 |
| Chr21:33599261 | IL10RB | rs2834178 | DOM | 0.66 (0.51–0.84) | 6.96 × 10−4 | 0.86 (0.63–1.18) | 0.363 | 0.73 (0.60–0.88) | 1.19 × 10−3 | 0.178 |
| Chr6:152461219 | ESR1 | rs9341066 | DOM | 1.96 (1.37–2.79) | 2.01 × 10−4 | 1.13 (0.74–1.75) | 0.568 | 1.57 (1.20–2.07) | 1.20 × 10−3 | 0.056 |
| Chr9:92665566 | SYK | rs1572104 | DOM | 0.63 (0.49–0.81) | 3.12 × 10−4 | 0.92 (0.65–1.31) | 0.660 | 0.72 (0.59–0.88) | 1.43 × 10−3 | 0.082 |
| Chr12:6766579 | LAG3 | rs11064386 | DOM | 1.68 (1.26–2.23) | 3.74 × 10−4 | 1.10 (0.76–1.57) | 0.618 | 1.42 (1.14–1.78) | 1.92 × 10−3 | 0.070 |
| Chr5:172137235 | DUSP1 | rs4868204 | DOM | 0.69 (0.53–0.91) | 9.40 × 10−3 | 0.84 (0.58–1.23) | 0.373 | 0.74 (0.59–0.93) | 8.67 × 10−3 | 0.421 |
| Chr7:41713523 | INHBA | rs12532252 | REC | 1.34 (1.00–1.79) | 0.050 | 1.17 (0.79–1.72) | 0.442 | 1.27 (1.01–1.61) | 0.042 | 0.580 |
Abbreviations: ADD, additive model; DOM, dominant model; p-het, P for heterogeneity test; REC, recessive model.
a
Adjusted according to age, sex, clinical stage, and treatment regimen.
b
Combined (meta) analysis based on fixed effects model. Boldface: P < 0.1.