Mean EQ-5Dindex in individuals with diabetes compared to control individuals by disease duration. Comparison (ANOVA) of the cohorts for the different years of disease duration found significant differences between the different cohorts of women with diabetes (p = 0.022), of female control individuals (p = 0.011), of men with diabetes (p = 0.002) and of male control individuals (p = 0.001), respectively. Post hoc tests could not detect between which cohorts the significance for women with diabetes lay. The test, however, showed significant differences men with diabetes between the 1983 cohort and all other cohorts (1992, p = 0.002; 1999, p = 0.007; 2008, p = 0.027), for female control individuals between the 2008 and 1983 cohorts (p = 0.025), and for male control individuals between the 1983 cohort compared with the 2008 (p = 0.002) and 1999 (p = 0.009) cohorts.