Table 4.

Multiple logistic regression model with cardiovascular adverse event and any adverse event as the dependent variable

	Post-intubation hypotension		Overall adverse event
Variable	OR (95% CI)	P Value	OR (95% CI)	P Value
Primary exposure
Age ≥ 65 years (vs. < 65 years)	2.6 (1.3–5.6)	0.01	1.0 (0.8–1.3)	0.97
Age (categorical variable)*
Age ≥ 80 years (vs. < 80 years)	2.4 (1.2–4.8)	0.01	0.98 (0.7–1.4)	0.92
Age, decile (ordinal variable: OR per each incremental decile)*	1.3 (1.1–1.7)	0.01	0.98 (0.9–1.1)	0.66
Covariate
Female (vs. male)	1.1 (0.6–2.2)	0.75	1.5 (1.1–1.9)	0.009
Primary indication		0.68		0.88
Medical	1.2 (0.5–3.2)		1.0 (0.7–1.5)
Trauma	1 [reference]		1 [reference]
Sedative (%)		0.001		0.14
No sedatives	0.1 (0.01–1.0)		1.2 (0.8–1.7)
Benzodiazepine	3.6 (1.3–10.0)		1.5 (1.0–2.3)
Propofol	1 [reference]		1 [reference]
Ketamine	1.0 (0.1–9.2)		0.9 (0.4–2.2)
Other†	5.9 (1.0–31.8)		2.1 (0.9–4.9)
Method		0.58		0.73
RSI	1.2 (0.6–2.5)		1.1 (0.7–1.6)
Non-RSI‡	1 [reference]		1 [reference]
Multiple attempts§ (vs. 2 or fewer attempts)	(0.4-2.6)	0.98	4.7 (3.4-6.4)	< 0.001

OR, odds ratio; CI, confidence interval; RSI, rapid sequence intubation.

*Sensitivity analyses.

†Defined as administration of thiopental, haloperidol or combination with any of the included sedative categories.

‡Defined as oral intubation without medication, with sedatives only, or with paralytics only, transnasal intubation and cricothyrotomy.

§Defined as 3 or more intubation attempts.