Table 1.

Eukaryote apoptosis-associated proteins and domain families that have been identified in prokaryotes and parasitic protozoa

Protein/domain family	Archaea	Bacteria	Parasitic Protozoa	Reference
Caspases/Paracaspases	Haloarchaea Euryarchaeota	Rhizobium	_	[40,41]
		Mesorizobium loti
Metacaspases	Euryarchaeota	α-proteobacteria	Leishmania spp.	[10,26,42-44]
		Cyanobacteria	Trypanosome spp.
		Deltaproteobacteria	Plasmodium spp.
AP-ATPases	Pyrococcus horikoshii	α-proteobacteria	_	[17,45]
		Cyanobacteria		[46]
		Actinomycetes
HtrA-like proteases	_	Many including Mesorizobium loti	_	[17]
Endonuclease G	_	_	Leishmania spp. Trypanosoma spp.	[29,47,48]
			Toxoplasma gondii
Apoptosis-inducing factor (AIF)	Many including Pyrococcus horikoshii	Many including	_	[17,38]
		Streptomyces coelicolor
TIR domain	_	Streptomyces coelicolor	_	[17]
Cytochrome c	Many including Aeropyrum pernix	α-proteobacteria Cyanobacteria Actinomycetes	Plasmodium spp.	[49]