Table 1.

Comparison of immunohistochemical markers between adjacent normal mucosa, tubular adenomas and RCT

Table 1	Pure RCT (case I)		Composite RCT (case II)
Markers	NM1	RC	NM2	TA	CTA	GC	RC
CK20	+++	neg.	+++	+++	+++	+	neg.
CK7	neg	neg.	neg.	neg.	neg.	neg.	neg.
CDX2	+++	neg.	+++	+++	+++	+	neg.
E-cadherin	++	neg.	++	++	++	+	neg.
β-catenina (a)	+	+	+	+	+	++	neg.
APC (c-ter)	++	++	++	++	+++	++	++
p53	neg.	++	neg.	+	+++	++	+
Vimentin	neg.	+++	neg.	neg	neg.	++	+++
CK18	+	+	+	++	++	+	++
CK19	++	++	++	++	++	+	++
CK-Pan	+++	++	+++	+++	+++	+++	+++
HDAC1	+	+++	+	+	++	++	+++
HDAC2	+	+++	+	+	++	++	+++
HDAC3	+	+++	+	+	++	++	+++
VEGFR1	neg.	neg.	neg.	+	+	neg.	neg.
VEGFR2	neg.	+++	neg.	neg.	neg.	++	++
MLH1	+++	neg.	+++	++	++	neg.	neg.
MSH2	+++	+	++	++	++	++	++
TS	+	+	+	++	++	+	+
INI1	+	+++	+	+	++	+	neg.

(+++): widespread occurrence, intense expression; (++): Varying distribution, moderate expression; (+): Limited occurrence, low expression; (−) no occurrence or negative. ^aβ-catenin nuclear localization; Abbreviations: Cytokeratin, CK; pure rhabdoid colorectal tumor, case I (RCTI); glandular (GC) and rhabdoid (RC) components of composite rhabdoid colorectal tumor, case II (RCTII); adjacent tubular adenomas (TA), cancerized and larger tubular adenoma (CTA) or normal mucosa (NM2) of case II. Case I, a pure RCT, is compared to the adjacent distant non-neoplastic mucosa (NM1); histone deacetylase, HDAC; vascular endothelial growth factor receptors, VEGFR; thymidylate synthase, TS.