Table 6.
Penetration of 10 μm (da) through respiratory tract regions relative to particles entering the respiratory tract
|
Vdaily (%-tile) |
Normal |
|
Gradual |
|
||||
|---|---|---|---|---|---|---|---|---|
| |
Augmentera |
Mouth-breathera |
Augmentera |
Oral onlya |
||||
| P(ET)avg | P(TB)avg | P(ET)avg | P(TB)avg | P(ET)avg | P(TB)avg | P(ET)avg | P(TB)avg | |
|
Male |
|
|
|
|
|
|
|
|
| 5% |
0.05b |
0.03 |
0.21 |
0.10 |
0.11 |
0.05 |
0.43 |
0.21 |
| 50% |
0.04 |
0.02 |
0.19 |
0.08 |
0.11 |
0.04 |
0.36 |
0.15 |
| 95% |
0.03 |
0.01 |
0.19 |
0.06 |
0.10 |
0.03 |
0.32 |
0.12 |
|
Female |
|
|
|
|
|
|
|
|
| 5% |
0.06 |
0.03 |
0.15 |
0.07 |
0.06 |
0.03 |
0.41 |
0.20 |
| 50% |
0.04 |
0.02 |
0.15 |
0.06 |
0.07 |
0.02 |
0.35 |
0.14 |
| 95% |
0.03 |
0.01 |
0.16 |
0.05 |
0.07 |
0.02 |
0.31 |
0.11 |
|
Child-B c |
|
|
|
|
|
|
|
|
| 5% |
0.05 |
0.02 |
0.16 |
0.08 |
0.16 |
0.08 |
0.38 |
0.18 |
| 50% |
0.03 |
0.01 |
0.15 |
0.06 |
0.14 |
0.06 |
0.31 |
0.13 |
| 95% |
0.02 |
0.01 |
0.14 |
0.04 |
0.13 |
0.04 |
0.27 |
0.09 |
|
Child-A d |
|
|
|
|
|
|
|
|
| 5% |
0.10 |
0.05 |
0.21 |
0.10 |
0.21 |
0.10 |
0.38 |
0.18 |
| 50% |
0.07 |
0.04 |
0.19 |
0.09 |
0.18 |
0.07 |
0.31 |
0.13 |
| 95% | 0.05 | 0.02 | 0.17 | 0.05 | 0.16 | 0.05 | 0.27 | 0.09 |
P(ET), extrathoracic penetration for 10 μm particles; P(TB), tracheobronchial penetration for 10 μm particles; aData are daily averages, all activity levels weighted by daily ventilation; bFraction penetration; cScaling factor in Equations 2 and 3 equal to 1.26; dScaling factor in Equations 2 and 3 equal to 1.0.