Table 1.

SRC-3 is subject to multiple post-translational modifications

PTM	SRC-3 Modifier	Effect on SRC-3	Modified Residue	Ref
Acetylation	CBP/p300	Inactivation	K626, K629, K630	89
Dephosphorylation	PP2A	Inactivation	S505, S543	22
	PP1	Stabilization	S101, S102	22
Methylation	CARM1	Inactivation, then Degradation	R1171	90
Phosphorylation	JNK	Activation	T24, S505, S543, S860, S867	32
	ERK	Activation	S505, S543	32
	p38MAPK	Activation	T24, S505, S543, S860, S867	32
	PKA	Activation	S857	32
	c-Abl	Activation	Y1357	34
	IKK	Activation	S857	32
	GSK3β	Activation, then Degradation	S505	77
	aPKC	Stabilization	S/T sites in a.a. 1031–1130 region	91
Ubiquitinylation	E6-AP	Degradation	Unknown	78
	SCFFbw7α	Degradation	K723, K786	77
	CUL-3 and RBX1	Degradation	Unknown	80
	CHIP	Degradation	Unknown	81
	SPOP	Degradation	N-terminal	83
SUMOylation	SUMO-1	Inactivation	K731	92

Notes for Table 1: Created by proteins from multiple intracellular signaling pathways, these modifications constitute a combinatorial code through which SRC-3 can integrate pathway-specific information to coordinate cellular outcomes. CBP, CREB-binding protein; PP2A, protein phosphatase 2A; PP1, protein phosphatase 1; CARM1, coactivator-associated arginine methyltransferase 1; JNK, c-Jun N-terminal kinase; ERK, extracellular-signal-regulated kinase; p38MAPK, p38 mitogen-activated protein kinases; PKA, protein kinase A; c-Abl, Abelson tyrosine kinase; GSK3β, glycogen synthase kinase 3; IKK, IκB kinase; aPKC, atypical protein kinase C; E6-AP, E6-associated protein; SCF, SKP1–cullin-1–F-box; Fbw7a, F-box and WD repeat domain-containing 7; CUL-3, Cullin-3; RBX1, RING box protein 1; CHIP, carboxyl terminus of Hsc70-interacting protein; SPOP, speckle-type POZ protein.