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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: J Immunol. 2010 Sep 29;185(9):5444–5452. doi: 10.4049/jimmunol.0903802

FIGURE 1.

FIGURE 1

SRC-3−/− mice are markedly susceptible to E. coli-induced peritonitis. A, SRC-3−/− mice exhibited the increased mortality during E. coli-induced peritonitis. After infection with E. coli, mice were observed every 12 h for 3 d. Each group consisted of 12 mice. BD, SRC-3−/− mice exhibited more severe multiple organ damage compared to wild-type mice. Liver injury was reflected by measurement of ALT and AST in plasma of SRC-3−/− and wild-type mice at 20 h post-infection (B and C). Kidney damage was assessed by determining the level of BUN in plasma of both mice at 20 h post-infection (D). Data are the means + SD of five mice per time point. ** p<0.01.