Skip to main content
. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: J Immunol. 2010 Sep 29;185(9):5444–5452. doi: 10.4049/jimmunol.0903802

FIGURE 4.

FIGURE 4

Phagocytosis of E. coli by peritoneal macrophages and neutrophils is decreased in SRC-3−/− mice. A and B, Phagocytosis of E. coli by peritoneal macrophages. Macrophages were incubated with E. coli-FITC at an m.o.i. of 100. FACS histogram is a representative of three independent experiments. C and D, Phagocytosis of E. coli by peritoneal neutrophils. FACS histogram is a representative of three independent experiments. Relative mean fluorescence intensity (MFI) was expressed in fold change relative to wild-type (+/+) values assigned a unit of 1. Data are the means + SD of four mice per group. E and F, The expression of SR-A (E) and CR3 (F) in macrophages was determined by real-time PCR. Data are the means + SD of four mice per group. G, The expression of SR-A protein on the surface of macrophages was analyzed by flow cytometry. Data shown are representative of three independent experiments. H, Bactericidal activity of macrophages from SRC-3−/− and wild-type mice. Data are the means + SD of four mice per group. *p<0.05, **p<0.01.