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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: J Immunol. 2010 Sep 29;185(9):5444–5452. doi: 10.4049/jimmunol.0903802

FIGURE 7.

FIGURE 7

Schematic model for the mechanism by which SRC-3 protects mice from E. coli peritonitis. Upon E. coli infection, macrophage SRC-3 suppresses proinflammatory cytokine synthesis to limit inflammatory responses and multiple organ damage. On the other hand, SRC-3 enhances bacterial clearance by macrophages through up-regulating the expression of catalase, Bcl-2, and SR-A to reduce macrophage apoptosis and to enhance phagocytosis of E. coli. Both actions help to prevent animal from E. coli peritonitis-induced lethality.