Table 1. CB2 mediated effects of 1,8-naphthyridine, pyridine and quinoline derivatives.

Drugs	% inhibition	% recovery
	−SR144528	+SR144528
CB74	*75.4±19.0	$46.0±3.2
VL23	*85.9±3.2	$35.5±1.5
AF4	*87,8±3.9	$31.1±6.8

In table 1 we reported the percent of inhibition ± standard deviation of CB74, VL23 and AF4 at the concentration of 10 µM. The values are the mean of five independent experiments (these values correspond to the histogram reported in figure 1 B of healthy donors).The values reported in the presence of our drugs (without SR144528, -SR144528) are statistically significant with respect to MBP activated cells (*p<0,01).

The last colon of the table shows the percent of cell recovery ± standard deviation obtained culturing our compounds in the presence of SR144528 (+SR144528). The values reported are the mean of five independent experiments. The statistical analysis has been performed considering the values obtained with the drugs in the presence of SR144528 with respect to drug treated cells in the absence of SR144528 (^$p<0,01).