Figure 8. Similarity clustering and STRING analysis of the regeneration-enriched genes selected by pairwise comparison between amputation and lateral wound.

A. Heat map of 85 probes (representing 44 genes with a assigned human Refseq homolog) up-regulated in regenerating but not or only weakly in the lateral wound samples shows a diversity of expression kinetics. log₂ values of standard scores of normalized signal are shown. Up-regulation is indicated by reds with increasing intensities, down-regulation by blues with increasing intensities. B. STRING analysis of the gene set showing only high confidence functional connections (confidence score ≥0.7). ECM remodeling network including MMPs and elastase is shown in yellow, epithelial organization network in brown and the limb bud network including WNT5A, MSX1, LHX2 in orange color balls. Five identifiers were not recognized by STRING 9.0 interface and therefore 39 candidates were considered). See also Figure S5.