Table 1.

Effect of fluvoxamine (25 mg/kg i.p.) or saline (control) on 5-HT synthesis rates in the rat brain regions and pineal body.

Structures	5-HT synthesis rate (pmol/g/min)a		ANOVA
	Controls (N=8)	Fluvoxamine (N=11)	Percent differenceb	F(1,17); p
Raphe nuclei
-Dorsal	144±18	140±18	−3%	0.22 ; <0.60
-Median	134±21	115±12	−14%	6.4; <0.02d
-Magnus	62±9	43±10	−32%	18.1 ; <0.0006c
Cortices
-Visual	30±5	41±7	38%	14.3; <0.001c
-Auditory	26±6	43±9	65%	21.4; <0.003c
-Parietal	29±7	39±9	37%	6.8; <0.02d
-Sensory-motor	32±7	43±12	36%	5.4; <0.04d
-Frontal	33±7	35±9	7%	0.27; >0.60
Basal ganglia
-Globus pallidus	39±10	48±7	25%	5.36; <0.04d
-Caudate-lateral	38±8	47±10	23%	4.4 ; <0.05d
-Caudate-medial	54±9	60±10	12%	1.81; >0.10
-Nucleus accumbens	65±9	68±6	4%	0.76; >0.30
Thalamus
-Ventral	32±5	42±9	31%	7.99; <0.010c
-Dorsal	38±6	46±9	23%	4.74; <0.050c
Hippocampus
-Ventral	42±5	59±9	43%	23.0; <0.0002c
-Dorsal	38±8	54±4	41%	33.0; <0.0003c
Substantia nigra
-Reticulata	28±4	34±7	23%	4.7; <0.05d
-Compacta	30±4	44±9	56%	16.7; <0.0008c
Geniculate body
-Medial	30±6	45±10	48%	14.1; <0.002c
-Lateral	43±7	47±9	8%	1.09; >0.3
VTA	43±6	50±9	15%	3.6; >0.07
MFB	48±6	39±9	−20%	6.00; <0.03d
Hypothalamus	34±5	40±6	18%	5.30; <0.04d
Superior colliculus	28±6	39±10	38%	7.60; <0.02c
Inferior colliculus	24±7	32±7	29%	6.0; <0.03d
Superior olive	34±17	34±11	2%	0.08; 1.000
Pineal body	705±262	1178±298	Not tested

^a5-HT synthesis rates are expressed as mean±SD. The number of animals is given in brackets.

^bCalculated as a percent (%) of the synthesis rates in the control group.

^cSignificant difference in 5-HT synthesis rates between the fluvoxamine and control group following the Benjamini–Hochberg correction.

^dIdentifies the brain regions with p<0.05 which lost significance following Benjamini–Hochberg correction.