Table 2. ANOSIM analysis between categories.

	B6 (8 weeks)		B6 (16 weeks)		BALB/C (feces)		BALB/C (caecum)		NOD		Human
	R	p	R	p	R	p	R	p	R	p	R	p
6. V- Lepob /J (8 weeks)	–	–	0.644	<0.001***	1.000	<0.001***	0.999	<0.001***	1.000	<0.001***	1.000	<0.001***
B6. V- Lepob /J (16 weeks)	0.219	<0.001***	–	–	1.000	<0.001***	0.998	<0.001***	0.998	<0.001***	1.000	<0.001***
BALB/c (feces)	0.808	<0.001***	0.888	<0.001***	–	–	0.883	<0.001***	0.999	<0.001***	1.000	<0.001***
BALB/c (caecum)	0.663	<0.001***	0.876	<0.001***	0.850	<0.001***	–	–	0.994	<0.001***	1.000	<0.001***
NOD	0.531	<0.001***	0.564	<0.001***	0.901	<0.001***	0.475	<0.001***	–	–	1.000	<0.001***
Human	0.911	<0.001***	0.888	<0.001***	0.975	<0.001***	0.851	<0.001***	0.829	<0.001***	–	–

Analysis of similarity (testing whether two or more groups are significantly different) was calculated between all categories based on rarefied (4500 reads per sample) weighted (regular font) and unweighted (bold font) distance matrices. Each pairwise comparison of two groups was performed using 1000 permutations. R values >0.75 are generally interpreted as clearly separated, R >0.5 as separated and R <0.25 as groups hardly separated [17].