Table 1. MIC and MBC values for S. aureus strains exposed to various antibiotics in the absence and presence of HAMLET.
Bacterial Strain | Antibiotics, MIC (µg/ml) | MIC Fold reduction | Antibiotics, MBC (µg/ml) | MBC Fold reduction | [HL]** to sensitize, µM | ||
Meth | Meth + HL * | Meth | Meth + HL * | ||||
NRS1 | >128 | 16 | >8 | >256 | 64 | >4 | 48 |
NRS70 | 32 | 1 | 32 | 128 | 4 | 32 | 3 |
NRS71 | >128 | 16 | >8 | >256 | 64 | >4 | 54 |
NRS100 | >128 | 8 | >16 | >256 | 64 | >4 | 18 |
NRS123 | 32 | 4 | 8 | >256 | 16 | >16 | 12 |
NRS384 | 16 | 2 | 8 | >256 | 8 | >32 | 6 |
10307570 | 16 | 2 | 8 | >256 | 16 | >16 | 6 |
11090306 | 2 | 1 | 2 | 64 | 4 | 16 | 0 |
Erm | Erm + HL * | Erm | Erm + HL * | ||||
NRS384 | 16 | 4 | 4 | >256 | 16 | >16 | 6 |
NRS123 | 0.5 | 0.25 | 2 | 16 | 4 | 4 | 0 |
Gent | Gent + HL * | Gent | Gent + HL * | ||||
NRS384 | 1 | 0.00625 | 160 | 16 | 4 | 4 | 0 |
NRS1 | >128 | 8 | >16 | >256 | 32 | >8 | 48 |
Vanc | Vanc + HL * | Vanc | Vanc + HL * | ||||
NRS384 | 1 | 0.5 | 2 | 16 | 8 | 2 | 0 |
NRS1 | 8 | 4 | 2 | 32 | 8 | 4 | 18 |
HL = HAMLET. Concentration used was 100 µg/ml (6 µM).
The last column describes the concentration of HAMLET required to make each strain sensitive to the respective antibiotic.