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. 2013 May 1;8(5):e63158. doi: 10.1371/journal.pone.0063158

Table 1. MIC and MBC values for S. aureus strains exposed to various antibiotics in the absence and presence of HAMLET.

Bacterial Strain Antibiotics, MIC (µg/ml) MIC Fold reduction Antibiotics, MBC (µg/ml) MBC Fold reduction [HL]** to sensitize, µM
Meth Meth + HL * Meth Meth + HL *
NRS1 >128 16 >8 >256 64 >4 48
NRS70 32 1 32 128 4 32 3
NRS71 >128 16 >8 >256 64 >4 54
NRS100 >128 8 >16 >256 64 >4 18
NRS123 32 4 8 >256 16 >16 12
NRS384 16 2 8 >256 8 >32 6
10307570 16 2 8 >256 16 >16 6
11090306 2 1 2 64 4 16 0
Erm Erm + HL * Erm Erm + HL *
NRS384 16 4 4 >256 16 >16 6
NRS123 0.5 0.25 2 16 4 4 0
Gent Gent + HL * Gent Gent + HL *
NRS384 1 0.00625 160 16 4 4 0
NRS1 >128 8 >16 >256 32 >8 48
Vanc Vanc + HL * Vanc Vanc + HL *
NRS384 1 0.5 2 16 8 2 0
NRS1 8 4 2 32 8 4 18
*

HL  =  HAMLET. Concentration used was 100 µg/ml (6 µM).

**

The last column describes the concentration of HAMLET required to make each strain sensitive to the respective antibiotic.