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. 2013 May 1;8(5):e63146. doi: 10.1371/journal.pone.0063146

Figure 4. In vivo MRI reveals VEGF overexpression alters the angiogenic phenotype of MDA-MB-231 tumors.

Figure 4

Representative functional MRI maps of the vascular volume from: (a) MDA-MB-231 and (b) MDA-MB-231 VEGF overexpressing tumor bearing animals. (c) Box-and-whisker plot comparing the vascular volume between MDA-MB-231 (n = 5) and MDA-MB-231-VEGF (n = 4) xenografts (*p = 0.0159 with the two-tailed Mann-Whitney U Test). Representative functional MRI maps of the permeability-surface area product from: (d) MDA-MB-231 and (e) MDA-MB-231 VEGF overexpressing tumor-bearing animals. (f) Box-and-whisker plot comparing the permeability-surface area product between MDA-MB-231 (n = 5) and MDA-MB-231-VEGF (n = 4) xenografts.