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. 2013 May 1;8(5):e63146. doi: 10.1371/journal.pone.0063146

Figure 7. Histological validation of the transformation of non-invasive MCF-7 tumors to the metastatic phenotype following VEGF overexpression.

Figure 7

Representative (40×) images of H&E stained lung sections from: (a) MCF-7, (b) MCF-7-VEGF, (c) MDA-MB-231 and (d) MDA-MB-231-VEGF tumor bearing animals. Cancer cells are indicated by solid arrows in each panel. (e) Comparison of the number of animals with cancer positive (CA +ve) and cancer negative (CA -ve) lungs for each type of breast cancer xenograft. Representative (40×) images of H&E stained lymph node sections from: (f) MCF-7, (g) MCF-7-VEGF, (h) MDA-MB-231 and (i) MDA-MB-231-VEGF tumor bearing animals. Cancer cells are indicated by solid arrows in each panel. (j) Comparison of the number of animals with cancer positive (CA +ve) and cancer negative (CA -ve) lymph nodes for each type of breast cancer xenograft.