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. 2013 May 1;8(5):e63055. doi: 10.1371/journal.pone.0063055

Figure 5. The cytotoxic effects of CD8+CTLs against breast cancer MDA-MB-415 cells.

Figure 5

The five types of CD8+CTLs, i.e., DC-CTL, Ad-null-CTL, MGBAp-CTL, and Ad-MGBA-CTL and Ad-MGBA-CTL (without TNF-α ) were added into MDA-MB-415 cell cultures at an E:T ratio of 10∶1, 20∶1, and 40∶1. 12 h later, breast cancer cell apoptosis rates were analyzed by FACS. The data showed that Ad-MGBA infected DCs-stimulated CD8+CTLs had the highest cytotoxic effect among these five types of CD8+CTLs. Ad-MGBA-CD8+CTL could efficiently lyse MDA-MB-415 cells at an E:T ratio of 20∶1.