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. 2013 May 1;8(5):e63399. doi: 10.1371/journal.pone.0063399

Table 1. The differences between brands of immunoglobulin products.

Brand A Brand B Brand C Brand D
Brand Name Gamimune N Intraglobin F Venoglobulin-S Flebogamma
Manufacturer Talecris Biotherapeutics, INC. Biotest Pharma GMBH Alpha Therapeutic Corp. Instituto Crifols S.A.
Country NC, U.S.A. Germany LA, U.S.A. Spain
Preparation Cold ethanol-PEG precipitation, diafiltration/acidification Cold ethanol-PEG precipitation, β-propiolactonation Cold ethanol-PEG precipitation, DEAE-Sephadex fractionation Cold ethanol-PEG precipitation, nanofiltration down to 20 nm
IgA conc. (ug/mL) 270 < = 2500 15.1 <50
IgM conc. (ug/mL) 76+/−15 < = 600 <11.1 trace
Osmolality (mOsmol/kg) 274 N/A N/A N/A
pH 4.0∼4.5 pH 6.6. Non acidic 5.0–6.0
Sugar content none glucose sorbitol sorbitol
IgG subclass
IgG 1 (%) 59.8 62.0 66.5 66.7
IgG 2 (%) 28.9 34.0 24.5 28.2
IgG 3 (%) 6.2 0.5 5.8 2.3
IgG 4 (%) 5.1 3.5 3.2 2.5
IgG MWD Mono 99%, dimer <1% Mono+dimer>90% Mono+dimer>95% Mono>99.8%
Period (years) 1997∼2008 1998∼2004 1998∼2006 2004∼2008