Table 1. The differences between brands of immunoglobulin products.
Brand A | Brand B | Brand C | Brand D | |
Brand Name | Gamimune N | Intraglobin F | Venoglobulin-S | Flebogamma |
Manufacturer | Talecris Biotherapeutics, INC. | Biotest Pharma GMBH | Alpha Therapeutic Corp. | Instituto Crifols S.A. |
Country | NC, U.S.A. | Germany | LA, U.S.A. | Spain |
Preparation | Cold ethanol-PEG precipitation, diafiltration/acidification | Cold ethanol-PEG precipitation, β-propiolactonation | Cold ethanol-PEG precipitation, DEAE-Sephadex fractionation | Cold ethanol-PEG precipitation, nanofiltration down to 20 nm |
IgA conc. (ug/mL) | 270 | < = 2500 | 15.1 | <50 |
IgM conc. (ug/mL) | 76+/−15 | < = 600 | <11.1 | trace |
Osmolality (mOsmol/kg) | 274 | N/A | N/A | N/A |
pH | 4.0∼4.5 | pH 6.6. | Non acidic | 5.0–6.0 |
Sugar content | none | glucose | sorbitol | sorbitol |
IgG subclass | ||||
IgG 1 (%) | 59.8 | 62.0 | 66.5 | 66.7 |
IgG 2 (%) | 28.9 | 34.0 | 24.5 | 28.2 |
IgG 3 (%) | 6.2 | 0.5 | 5.8 | 2.3 |
IgG 4 (%) | 5.1 | 3.5 | 3.2 | 2.5 |
IgG MWD | Mono 99%, dimer <1% | Mono+dimer>90% | Mono+dimer>95% | Mono>99.8% |
Period (years) | 1997∼2008 | 1998∼2004 | 1998∼2006 | 2004∼2008 |