Table 2.

Hippocampal gene expression 6 h after sgp130 and LPS.

		Vehicle (ICV)		sgp130 (100 ng) (ICV)		p - value
Age	Gene	Saline (i.p.)	LPS (10 μg) (i.p.)	Saline (i.p.)	LPS (10μg) (i.p.)	sgp130	LPS	sgp130 × LPS
Adult	IL-1β	0.99± 0.20	8.98± 2.54	1.25± 0.36	7.80± 1.48	0.873	<0.001*	0.536
	IL-6	1.34± 0.52	12.00± 4.61	0.864± 0.28	6.70± 2.29	0.096	<0.001*	0.180
	MHC-II	0.67± 0.26	0.79± 0.19	0.66± 0.22	0.83± 0.25	0.778	0.984	0.513
	iNOS2	0.91± 0.16	2.71± 1.85	0.78± 0.28	2.73± 0.65	0.951	0.059	0.632
	ADAM10	0.82± 0.20	1.38± 0.05	1.05± 0.15	1.17± 0.64	0.711	0.049*	0.842
	ADAM17	1.09± 0.17	0.98± 0.45	0.96± 0.23	0.88± 0.31	0.860	0.977	0.621
	SOCS1	1.43± 0.30	1.34± 0.36	1.58± 0.35	1.32± 0.22	0.632	0.187	0.545
	SOCS3	1.01± 0.10	7.69± 4.67	0.74± 0.14	5.39± 2.54	0.137	<0.001*	0.553
	ICAM-I	1.07± 0.25	3.76± 1.98	0.90± 0.10	2.22± 0.82	0.753	0.040*	0.366
	VCAM-I	1.00± 0.07	2.08± 0.54	1.13± 0.28	1.40± 0.45	0.837	0.048*	0.411
Aged	IL-1β	2.67± 0.99	16.53± 2.15	3.31± 1.17	10.97± 4.47	0.115	<0.001*	0.131
	IL-6	5.41± 2.23	22.75± 5.67	2.17± 0.85	11.10± 3.21	0.047*	<0.001*	0.031*
	MHC-II	1.97± 0.47	2.49± 1.12	0.88± 0.43	0.69± 0.21	0.051*	0.009*	0.039*
	iNOS2	0.98± 0.22	2.96± 1.26	0.78± 0.28	2.91± 1.84	0.971	0.045*	0.732
	ADAM10	1.06± 0.13	1.51± .18	1.07± 0.25	1.45± 0.27	0.643	0.057	0.115
	ADAM17	2.17± 0.39	2.61± 0.82	1.30± 0.13	2.01± 0.36	0.043*	0.321	0.431
	SOCS1	0.82± 0.32	2.70± 1.93	1.17± 0.18	2.96± 0.54	0.718	0.074	0.333
	SOCS3	1.23± 0.19	11.33± 2.55	1.09± 0.18	11.95± 2.20	0.340	<0.001*	0.513
	ICAM-I	4.34± 2.14	4.92± 2.64	1.81± 0.89	5.32± 1.35	0.110	0.101	0.215
	VCAM-I	1.86± 0.68	2.14± 0.80	1.29± 0.56	1.36± 0.42	0.221	0.445	0.655

Fold Change

^*a significant difference per treatment group